Collagen Plus Joint is one of the most comprehensive formulas available on the market today

How does it work?

Collagen Plus Joint provides targeted precursors and cofactors known to be involved in the biochemical processes that support healthy connective tissue in the skin, tendons, ligaments, cartilage, joints, and bone extracellular matrix. This formulation contains patented hyaluronic acid, MSM, free-form amino acids, key minerals and vitamin C.

Joint health is a growing concern as we age, with an estimated 54.4 million adults in the United States alone suffering from arthritis and other joint-related issues according to the Centers for Disease Control and Prevention (CDC). The pain and discomfort associated with joint problems can significantly impact one's quality of life, making everyday tasks increasingly challenging. As we grow older, our body's natural production of collagen decreases, leading to a decline in the strength and flexibility of our joints. Collagen Joint Plus, with its powerful blend of collagen and other essential nutrients, is designed to target the root cause of these joint issues, providing a comprehensive solution to promote overall joint health.

Not only is Collagen Joint Plus an effective remedy for those already experiencing joint pain, but it also serves as a preventative measure to protect joints and maintain their integrity as we age. By combining collagen, vitamin C, zinc, manganese, L-lysine, L-proline, hyaluronic acid, and MSM, this supplement works synergistically to strengthen connective tissues, improve joint lubrication, reduce inflammation, and support the production of collagen. This unique formula helps to restore and maintain joint function, while promoting healthier, more youthful skin as an added bonus. Don't let joint pain hold you back any longer – Collagen Joint Plus is the perfect solution to support your active lifestyle and keep you moving with ease throughout the years.

Dr. Nandi's Collagen Plus Joint is formulated for optimal joint support, pain reduction and improved range of motion.

Hyaluronic Acid Extract†

Collagen Plus Joint is a patented , high-molecularweight hyaluronic acid (HA), which enhances the viscoelastic, lubricating properties of synovial fluid. In addition, it contains collagen and other glycosaminoglycans (GAGs) to enhance skin and joint health. Hyaluronic acid also plays a role in the biophysical, biochemical and cell regulation processes in joint synovial tissues. Scientific evidence shows that Collagen Plus Joint supports chondrocytes and synovial cells function, and is two to four times more active than fermented sources of HA in nourishing and supporting the health of synovial fluid.1,2 The latest clinical research includes HA in proactive and maintenance approaches to joint care that supports normal range-of-motion. Research suggests that Collagen Plus Joint supports the quality of synovial fluid by positively influencing synovial HA concentration, and by reducing the expression of degradative factors in synovial fluid.3-6

Specific Precursors†

Collagen is comprised of and formed from the amino acids proline and lysine. Lysine is an essential amino acid the body relies on adequate dietary intake for its involvement in the synthesis of connective tissues. Proline is well-known for its involvement in the triple helix of collagen—it is regularly spaced with glycine in the amino acid sequence of collagen fiber, which together comprise about 50% of total collagen sequencing. Proline contributes to not only collagen formation, but muscle, tendons and skin. Lysine helps support the linking and stabilization of collagen, and contributes to the collagen matrix formation of veins, arteries and capillaries. During procollagen synthesis, both proline and lysine are hydroxylated to hydroxyproline and hydroxylysine, a reaction requiring vitamin C as a cofactor.9-11 Inadequate levels of vitamin C can impact this reaction, resulting in incomplete formation of the helical structure, in which leads to a delicate and easily destroyed structure. Vitamin C is combined with two amino acids—lysine and proline—to form procollagen. Procollagen is then used to manufacture one of several types of collagen found in different tissues throughout the body.12-13 Furthermore, an animal study suggests that serum ascorbate levels influence fluid accumulation in the joint, reinforcing the importance of this cofactor in joint health.12 Targeted Cofactors Zinc is an essential trace mineral that supports DNA synthesis, cell division, cell membrane structure, immune function, and protein synthesis. Requirements are highest when the body’s repair system is most active. MSM is responsible for the flexible disulfide bonds between cells, including those that make up connective tissue and the skin. It blocks undesirable chemical and physical cross-linking of collagen and preserves connective tissue pliancy, which is crucial for supporting healthy collagen. MSM has been shown to significantly increase plasma glutathione levels, an additional benefit in maintaining collagen’s defensive mechanisms against oxidative stress.

Multiple clinical studies also show that MSM, in combination with other joint health ingredients, supports tendon and joint health.6-7 Manganese assists the growth and development of normal bone and the synthesis of cartilage. Manganese is also a structural component of antioxidant enzymes, and aids in amino acid production. During the tissue synthesis process, which requires an increased production of collagen, manganese is required for the activation of prolidase, an enzyme that functions to provide the amino acid proline, for collagen formation in human skin cells.15 Nutritional co-factors required for tissue regeneration include zinc, vitamin C and amino acids. Inadequacy of these nutrients impacts endogenous collagen production and connective tissue synthesis.

Directions 2 capsules per day or as recommended by your health care professional.

Does Not Contain Gluten, yeast, artificial colors or flavors.

Cautions If you are pregnant or nursing, consult your physician before taking this product.

References

1. Torrent A, Ruhí R, Theodosakis J, et al. Comparative efficacy of IB0004, extracted hyaluronic acid (HA) and fermented HA on the synthesis of endogenous HA by human synoviocytes. Osteoarthritis Cartilage. 2009;17(Suppl 1):S278-79. – 10x HA secretion 2. Torrent A, Ruhí R, Martínez C, et al. Anti-inflammatory activity and absorption of a natural rooster comb extract (Hyal-Joint®). Osteoarthritis and Cartilage. 2010 Oct;18(Suppl 2):S246-47. doi:10.1016/ S1063-4584(10)60577-8. – reduction of inflammation 3. Möller I, Martinez-Puig D, Chetrit C. Oral administration of a natural extract rich in hyaluronic acid for the treatment of knee OA with synovitis: a retrospective cohort study. Clinical Nutrition Supplements 2009;4(2):171-172 4. Martinez-Puig D, Möller I, Fernández C, Chetrit C. Efficacy of oral administration of yoghurt supplemented with a preparation containing hyaluronic acid (Collagen Plus Joint) in adults with mild joint discomfort: a randomized, double-blind, placebo controlled intervention study. Mediterranean Journal of Nutrition and Metabolism 2013;6:63–68. 5. Sánchez J, Bonet ML, Keijer J, v an Schothorst EM, Mölller I, Chetrit C, Martinez-Puig D, P alou A. Blood cells transcriptomics as source of potential biomarkers of articular health improvement: effects of oral intake of a rooster combs extract rich in hyaluronic acid. Genes & Nutrition 2014; 9: 417 6. Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J 2013;12(1):154. 7. Brien S, Prescott P, Lewith G. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methysulfonylmethane in the treatment of osteoarthritis of the knee. 8. Brien S, Prescott P, Lewith G. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med. 2011;2011:528403. doi: 10.1093/ecam/ nep045. [PMID: 19474240] 9. S Murad, D Grove, K A Lindberg, G Reynolds, A Sivaraja, S R Pinnell. Regulation of collagen synthesis by acorbic acid. Proc Natl Aca Sci USA. 1981 May; 78(5):2879-2882 10. 10. Boyera N, Galey I, Bernard BA. Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. Int J Cosmet Scie. 1998 Jun;20(3):151-8. Doi: 10.1046/j. 1467-2494.1998.171747.x. 11. Andreas Herchenhan, Franziska Uhlenbrock, Pernilla Eliasson, et al. Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells. J Biol Chem. 2015 Jun 26;290(26):16440-16450. 12. Simões SI, Eleutério CV, Cruz ME, et al. Biochemical changes in arthritic rats: dehydroascorbic and ascorbic acid levels. Eur J Pharm Sci. 2003;18(2):185-89. [PMID: 12594012] 13. Li P, Wu G. Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth. Amino Acids. 2017 Sep 20. 14. Frey J, Raby N. Lysine and collagen. Annales de Biologie Clinique. 01991, 49 (1):36-39. 15. Muszynska A, Palka J, Gorodkiewicz E. The mechanism of daunorubicin-induced inhibition of prolidase activity in human skin fibroblasts and its implication to impaired collagen biosynthesis. Exp Toxicol Pathol. 2000 May;52(2):149-55.

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