Pure N- Acetyl Cysteine is one of the most comprehensive formulas available on the market today

How does it work?

Pure N-Acetyl Cysteine is one of the few antioxidants found to raise glutathione levels. Glutathione is an important antioxidant used in many different metabolic processes within the body. Maintaining adequate levels is important to maintaining the health of the respiratory, hepatic and immune systems. It is also important in supporting antioxidant protection of lipids and proteins and supporting the normal response to inflammation.1-7 Glutathione is not well absorbed by the body when taken orally, so it can be difficult to sustain adequate glutathione levels. Pure NAC has been shown to significantly increase glutathione levels. Pure NAC is also capable of reducing the viscosity of mucous and is also used to support respiratory and pulmonary health

An increasingly large number of people are suffering from the detrimental effects of environmental toxins and pollutants, as well as chronic respiratory conditions. In the United States alone, over 25 million people have asthma, and more than 16 million adults are diagnosed with chronic obstructive pulmonary disease (COPD). These respiratory issues, combined with the constant exposure to toxins from air, water, and food sources, pose significant health risks that can impact our quality of life.

Pure N-Acetyl cysteine (NAC) is a powerful supplement that can provide a solution to these prevalent health concerns. NAC aids in the production of glutathione, a critical antioxidant that helps to detoxify environmental toxins and pollutants, supporting liver function and overall health. Additionally, NAC's mucolytic properties improve respiratory function by breaking down and thinning mucus, providing relief for those suffering from chronic respiratory conditions. By incorporating NAC into your daily supplement regimen, you can effectively combat these issues, protecting your body from harmful toxins and promoting healthier respiratory function. Whether you're aiming to improve your lung health or seeking a powerful detoxification aid, Pure N-Acetyl cysteine is a valuable addition to your wellness routine.

What is Pure NAC? Pure N-Acetyl cysteine is an amino acid that boosts antioxidant function and is commonly used as an agent to help clear sinus and airway congestion caused by mucus overproduction. Pure NAC is a source of the conditionally essential amino acid L-cysteine and is a precursor to the tripeptide glutathione, an essential intracellular antioxidant, and therefore supports antioxidant and cellular detoxification pathways in the body. In addition, a growing body of research also highlights the role of Pure NAC in supporting neuropsychiatric health. Each capsule of Pure Pure N-Acetyl Cysteine provides 500 mg of this versatile amino acid.

Overview

Pure N-Acetyl Cysteine is one of the few antioxidants found to raise glutathione levels. Glutathione is an important antioxidant used in many different metabolic processes within the body. Maintaining adequate levels is important to maintaining the health of the respiratory, hepatic and immune systems. It is also important in supporting antioxidant protection of lipids and proteins and supporting the normal response to inflammation.1-7 Glutathione is not well absorbed by the body when taken orally, so it can be difficult to sustain adequate glutathione levels. Pure NAC has been shown to significantly increase glutathione levels. Pure NAC is also capable of reducing the viscosity of mucous and is also used to support respiratory and pulmonary health.

Detox Support and Antioxidant Protection†

Though studies have shown the absorption of oral glutathione to be limited,8 supplementation with Pure NAC has been shown to significantly increase circulating levels of glutathione in the body.9,10 Increasing glutathione levels in turn increases the production of specialized antioxidant enzymes such as glutathione peroxidase, glutathione reductase and detoxification enzymes such as glutathione S-transferases. Through the activity of these enzymes, Pure NAC protects the body from oxidative damage, increases phase II detoxification, and enhances the normal breakdown of toxins and other metabolic byproducts of the body.

Respiratory Function†

Studies show Pure NAC supports normal mucous production and may positively support pulmonary and respiratory function, especially when consumed over a prolonged period. [11,12] A clinical trial of 100 smokers found Pure NAC significantly improved measures of pulmonary health,13 and high-dose Pure NAC taken over a one year period resulted in significantly improved small airway clarity and decreased frequency of respiratory challenges.14 A systematic review found Pure NAC to be effective in supporting children’s pulmonary health as well.15 Pure NAC was also shown to support pulmonary health after inhalation of mustard gas.16

Neuropsychiatry Health†

More recently, research has pointed to the role of Pure NAC in targeting a diverse array of factors related to the neuropsychiatric health. Pure NAC has been shown to protect neurons from oxidative damage, and to improve neurotransmitter production, mitochondrial function and inflammatory balance.17 Studies have also highlighted the role of Pure NAC in modulating oxidative stress as its mechanism of action in neuropsychiatric health.18 In one 12-week, doubleblind, randomized, placebo-controlled study of NAC in children with developmental delay, NAC resulted in significant improvements in irritability scores.19

Directions 1 or more capsules per day or as recommended by your health care professional.

Does Not Contain Gluten, corn, yeast, artificial colors or flavors.

Cautions If you are pregnant or nursing, consult your physician before taking this product.

References

1. De Rosa SC, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 2000 Oct;30(10):841-2. [PMID: 11029607]. 2. Atkuri KR, Mantovani JJ, Herzenberg LA, et al. N-Acetylcysteine-a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Review. [PMID: 17602868]. 3. White AC, Thannickal VJ, Fanburg BL. Glutathione deficiency in human disease. J Nutr Biochem. 1994;5:218-26.http://www. sciencedirect.com/science/article/pii/0955286394900396 Updated January 27, 2003. Accessed February 27, 2012. 4. Pace GW, Leaf CD. The role of oxidative stress in HIV Disease. Free Rad Biol Med. 1995;19:523-8. [PMID: 7590404].5. Favier A, Sappey C, Leclerc P, et al. Antioxidant status and lipid peroxidation in patients infected with HIV. Chem Biol Interact. 1994 Jun;91(2-3):165-80. Review. [PMID: 8194133]. 6. Nakamura H, Masutani H, Yodoi J. Redox imbalance and its control in HIV infection. Antioxid Redox Signal. 2002 Jun;4(3):45564. [PMID: 12215212]. 7. Roberts RL, Aroda VR, Ank BJ. N-acetylcysteine enhances antibody-dependent cellular toxicity in neutrophils and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients. J Infect Dis. 1995 Dec;172(6):1492-502. [PMID: 7594708]. 8. Witschi A, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43:667-9. [PMID: 1362956]. 9. De Rosa SC, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 2000 Oct;30(10):841-2. [PMID: 11029607]. 10. Atkuri KR, Mantovani JJ, Herzenberg LA, et al. N-Acetylcysteine-a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Review. [PMID: 17602868]. 11. Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebocontrolled clinical trials. Clin Ther. 2000 Feb 22(2):209-21. [PMID: 10743980]. 12. Yalçin E, Altin F, Cinhüseyinoglue F, et al. N-acetylcysteine in chronic blepharitis. Cornea. 2002 Mar;21(2):164-8. [PMID: 11862087]. 13. Mirhosseini SJ, Forouzannia SK, Nasirian M, Ali-Hassan- Sayegh S. Saudi J Anaesth. N-acetylcysteine instead of theophylline in patients with COPD who are candidates for elective off-pump CABG surgery: Is it possible in cardiovascular surgery unit? Saudi Journal of Anaesthesia. 2013 Apr;7(2):151-4. doi: 10.4103/1658354X.114069. 14. Tse HN, Raiteri L, Wong KY, Yee KS, Ng LY, Wai KY, Loo CK, Chan MH. High-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE study. Chest. 2013 Jul;144(1):106-18. doi: 10.1378/chest.12-2357.. 15. Chalumeau M, Duijvestijn YC. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease. Cochrane Database Syst Rev. 2013 May 31;5:CD003124. doi: 10.1002/14651858. CD003124.pub4. 16. Jugg B, Fairhall S, Smith A, Rutter S, Mann T, Perrott R, Jenner J, Salguero J, Shute J, Sciuto AM. N-acetyl-L-cysteine protects against inhaled sulfur mustard poisoning in the large swine. Clin Toxicol (Phila). 2013 May;51(4):216-24. doi: 10.3109/15563650.2013.780208. Epub 2013 Apr 2. 17. Berk M, Malhi GS, Gray LJ, Dean OM. Trends Pharmacol Sci. 2013 Mar;34(3):167-77. doi: 10.1016/j.tips.2013.01.001. Epub 2013 Jan 29. The promise of N-acetylcysteine in neuropsychiatry. 18. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008 Sep;11(6):851-76. doi: 10.1017/ S1461145707008401. Epub 2008 Jan 21. 19. Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry. 2012 Jun 1;71(11):956-61. doi: 10.1016/j. biopsych.2012.01.014. Epub 2012 Feb 18.

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